The state of Massachusetts currently has 11 active clinical trials seeking participants for Insomnia research studies. These trials are conducted in various cities, including Boston, Worcester, Springfield and Burlington.
Brief Cognitive Behavioral Therapy to Enhance Benzodiazepine Deprescribing
Recruiting
The goal of this clinical trial is to conduct a single-arm pilot trial of a brief cognitive-behavioral therapy-enhanced benzodiazepine deprescribing intervention in 20 older adults (aged ≥55 years) prescribed chronic benzodiazepines by their primary care clinicians.
Gender:
All
Ages:
55 years and above
Trial Updated:
06/20/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Benzodiazepine Use, Insomnia, Anxiety
National Adaptive Trial for PTSD Related Insomnia
Recruiting
Many Veterans with posttraumatic stress disorder (PTSD) have trouble sleeping or have frequent nightmares. So far, no medication has been approved for treatment of insomnia in PTSD. The purpose of this research study is to find out if taking medications called trazodone or eszopiclone can help decrease symptoms of insomnia in patients with PTSD. PTSD is a form of intense anxiety which sometimes results from severe trauma. Symptoms may include nightmares, flashbacks, troublesome memories, difficu... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
06/07/2024
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: Insomnia
A Hybrid Effectiveness Implementation Trial Evaluating Behavioral Treatments for Insomnia for Socioeconomically Disadvantaged Adults in Primary Care
Recruiting
The overall objective of this study is to conduct a randomized effectiveness-implementation trial to test the non-inferiority of tele-Brief Behavioral Treatment for Insomnia vs. tele-Cognitive-Behavioral Therapy for Insomnia among socioeconomically disadvantaged adults with insomnia in the primary care setting.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/02/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Insomnia
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Recruiting
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.
Gender:
All
Ages:
Between 0 years and 20 years
Trial Updated:
03/29/2024
Locations: Boston Children's Hospital, Boston, Massachusetts +1 locations
Conditions: Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Hemophilia, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome
Sleep Treatment Education Program for Young Adult Cancer Survivors (STEP-YA)
Recruiting
The purpose of the study is to learn if a single online education session, with or without individualized coaching sessions, can help improve young adult cancer survivors' (YACS) sleep. The name of the study intervention is Sleep Treatment Education Program for Young Adult Cancer Survivors (STEP-YA).
Gender:
All
Ages:
Between 20 years and 39 years
Trial Updated:
03/20/2024
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Insomnia, Insomnia Due to Medical Condition, Cancer
Sleep Treatment Education Program-1 (STEP-1)
Recruiting
The purpose of the study is to learn if single session online education programs can help improve cancer survivors' sleep.
Gender:
All
Ages:
Between 40 years and 89 years
Trial Updated:
03/20/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Cancer Survivors, Insomnia
Biomarker Profiling in Individuals at Risk for Prion Disease
Recruiting
We are doing this research to identify biomarkers in individuals who are at-risk for familial prion disease. We hope to use these biomarkers to predict timing of disease onset in pre-symptomatic individuals and to guide the direction of future clinical trials.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
03/11/2024
Locations: Alzheimer's Clinical and Translational Research Unit, Charlestown, Massachusetts
Conditions: CJD (Creutzfeldt Jakob Disease), Prion Diseases, GSS, FFI, Familial Fatal Insomnia
Training in Evidence-based Treatments in Psycho-Oncology
Recruiting
The goal of this research study is to train psychotherapists to administer individualized evidence-based psychotherapies in a cancer care setting to participants with elevated levels of distress due to their illness and/or treatment. The intervention will mirror clinical care in psycho-oncology in which the therapist, collaboratively with their supervisor, will choose specific components of the following evidence-based treatments to administer based on the clinical presentation of the patient a... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/12/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Distress, Emotional, Depression, Anxiety, Fatigue, Pain, Insomnia
Suvorexant and Sleep/Delirium in ICU Patients
Recruiting
Investigators will evaluate the efficacy of postoperative oral suvorexant treatment on nighttime wakefulness after persistent sleep onset (WASO) among adult cardiac surgical patients recovering in the cardiac intensive care unit (ICU). The study include patients ≥ 60 years old undergoing coronary artery bypass graft surgery (CABG), with or without valve surgery (aortic or mitral). Patients will receive either oral suvorexant or placebo for 7 nights starting the night after extubation. The primar... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
11/15/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Insomnia, Sleep Fragmentation, Sleep Initiation and Maintenance Disorders, Postoperative Delirium
The Effect of Sleep Loss on Emotion Regulation
Recruiting
The study is designed to investigate the impact of three nights of sleep restricted to 4 hours per night, on the processing and regulation of emotional information compared to Insomnia Disorder and control. The investigators will address and attempt to answer two questions. (i) How do three nights of reduced sleep or a diagnosis of Insomnia Disorder affect the processing and regulation of emotional information compared to typical, undisturbed sleep? (ii) What overlapping and distinct neural mec... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
07/25/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Sleep, Insomnia, Sleep Deprivation
Efficacy of Suvorexant in the Treatment of Insomnia in Midlife Women With Pre-Diabetes
Recruiting
The aim of this study is to determine if suvorexant can help treat the severity of insomnia in midlife women who are pre-diabetic.
Gender:
Female
Ages:
Between 40 years and 65 years
Trial Updated:
02/16/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Insomnia, Diabetes, Menopause